I purchase Mistyfuse on a roll from the Mistyfuse Website, and I have covered my worktable with teflon. This makes it easy to apply the fusible to the fabric. I am using fabric leftover from Reflections - which is a wholecloth quilt of hand dyed fabric.
I cut the binding fabric into 1 1/4" strips (you could use any size, but this is what I like). I lap the binding about 1/2" over the top edge of the quilt, then fuse it in place.